Antibody cocktail promises safer stem cell therapy

Fears that stem cell therapies could seed a bizarre form of tumour may be calmed by a cocktail of antibodies. Because human embryonic stem cells (ESCs) can develop into any type of cell, they hold great promise in the field of regenerative medicine, which aims to replace cells or tissues lost to injury or disease. But their broad developmental capacity could also be their undoing: if any undifferentiated cells remain in a culture of, say, neurons grown from ESCs, they could run riot after being transplanted into a patient. The concern is that they might form tumours known as "teratomas", strange mixtures of tissues that can even include teeth and hair. The same fears surround induced pluripotent stem cells (iPSCs) – genetically <a href="http://www.afashionbuy.com/Handbags-Coach-Handbag-f2-39-c3-20.html"><strong>cheap coach handbags sale</strong></a> reprogrammed cells that mimic the properties of ESCs. To find a way of purging unwanted ESCs from cultures growing into other cell types, researchers led by Chad Tang and Micha Drukker – working in the lab of Irving Weissman at Stanford University, California – screened a library of antibodies against human ESCs to find those that bound most strongly to the cells. One antibody, which turned out to recognise a previously unknown carbohydrate dubbed SSEA-5, came out "at the top of the heap", says Weissman. Next the researchers turned to a method called fluorescence-activated cell sorting (FACS), which can separate cells depending on whether they carry an antibody tagged with a fluorescent label. They stuck such a fluorescent label to their new antibody, before adding it to human <a href="http://www.afashionbuy.com/"><strong>cheap Louis Vuitton replica handbags</strong></a> ESCs that were developing into blood cells. Then they used FACS to pick out cells the antibody bound to. Finally, they injected the remaining cells into mice to see if they formed teratomas. By itself, the new antibody did not completely purge the offending cells. But when it was combined with two other antibodies that also target molecules found on ESCs, no teratomas formed. "This is a proof of concept," says Tang, who notes <a href="http://www.afashionbuy.com/Handbags-Coach-Handbag-f2-39-c3-20.html"><strong>cheap coach designer handbags</strong></a> that different combinations of antibodies may be required for cultures developing into different types of cells. Two companies – Geron, based in Menlo Park, California, and Advanced Cell Technology (ACT) – are now running clinical trials of cells grown from human ESCs to treat spinal injuries and some forms of blindness respectively. Both had to provide extensive evidence from animal experiments to convince the US Food and Drug Administration that the transplanted cells will not form teratomas. Robert Lanza, who heads ACT's research labs in Marlborough, Massachusetts, warns that the new technique will not eliminate the need for animal safety studies. But he says that it may be useful in purifying certain cell types that can be cultured only for short periods, and so will be found only in cultures that may still contain many ESCs. "It could be the crucial step that allows partially <a href="http://galerija.myexit.org/displayimage.php?pos=-2277"><strong>The GHD Hair Straightener Australia's exterior looks good - 海归网</strong></a> differentiated cultures to be used clinically," he says. Journal reference: Nature Biotechnology, DOI: 10.1038/nbt.1947 If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.

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Learn and enthusiastic, diligent Mo Friends of the wave often helps students to draw water intake

reporter Huang Lijian (Reporter Fung) If there is no mother, Mo Friends of the wave that live and have lost the spirit of regeneration pillar. Therefore, he chose to drop out when his mother was seriously ill for two years, returned home to take care of the mother of Guizhou.
towards the end of freshman year leave of absence to go home

22-year-old Mo Friends of the wave,nike free 3.0, it is now, Xidian University, Mechanical Design, Manufacturing and Automation of the sophomore students. Yesterday morning, he was busy for the final exam review. The tall, thin, pale, shy of the big boys tend to speak fast. But the mention of his mother, tears in the eyes will immediately flashed.
Mo Friends of the wave of home in a new field in Libo County, Guizhou Province village of the mountains. 4 years old he lost his father, a poor mother alone to care for him and the little sister was two years older.
2006 年 9 months,air max 24 7, was admitted Mo Friends of the wave of Xidian University. Sister was not on the third year,nike air max 2009, have the time to take care of her. In 2007, the mother's illness more and more important,nike free sale, his hands numb, unable to eat anything,air max shoes,
time, the Friends of body waves in Mo Xian, the heart long to fly back to the mother. got into bed and secretly living tears.
year in June, there is still a month from the final exam. Mo Friends of the wave, but the decision: to drop out to care for her mother.
Mo Friends of the waves but also for academic concerns, the mother was strongly against his son home, too much of course. , so people called to live in the world. procedures, returned to my mother.
farm work, cooking, on the high school have started when the 7 am every morning, he would give his mother cook rice porridge, and then come down to earth shop and go to the fields. 13:00, he began to steamed rice, stir-fry,
lunch, MO Friends of the wave to continue to feed the pigs, cattle ... ... dinner until 9 pm, or rice and cabbage. Miserably, mother and son have been accustomed to for years, but can be mother, Mo Friends of the wave with both full and happy, watching the mother can come down to earth a little bit slowly, give their own cooking, he was glad.
two years to take care of his mother, Mo Friends of the wave has to work six months in Guiyang, did foot, sales and repair. 500-800 yuan a month to have income. In addition to living expenses, save some money he sent to his sister, bought some medicine and nutrition to his mother.
2009 年 9 months, the mother has returned to self-care ability. Mo Friends of the wave and Beiqishubao back to school to school.
government to build the new house is nearing completion

go back to school, senior year students have started their studies. No two years, the students said he was mature, and more silent. As late admissions, MO Friends of the wave into a new collective. When the students learned that his two-year leave of absence to care for her mother,
Mo schools are as much as possible to help the Friends of waves, through appropriate subsidies or fee waivers to ease his financial burden. But the mother's illness and the economic pressure is still often let Mo Friends of the wave of breath, , no matter how tough, I have to stick to it. Perhaps, Zhu Jia, and students can not solve the super-Mo Friends of the wave of the specific difficulties, house down, Mo Friends of the wave to the leadership of Guizhou Province, wrote to tell of the predicament. Currently, local government is to build a 70 square meter Mo houses. Can not cross two weeks, Mo Friends of the wave will leave home, he can in the room with my mother over Spring Festival.

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Taiyuan Xinhua
March 16 (Xinhua Hu Jingguo) in Taiyuan City Commercial Bank was the (now Merchants Bank) great Tian Wang Ying Pun branch president , in violation of the state loans, the amount of more than 10 million yuan , Cause huge property losses to the bank . Recently, Tian Hong , found guilty of illegal loans to the crime , was sentenced to Taiyuan Xiaodian District Court of First Instance 6 years , fined 120,nike air max 95,000 yuan .

Tian Hong , 63 , who from 1992 to 2000, appointed President of Taiyuan City Commercial Bank branch . July 1998-December 1999 , the Shanxi Xiaoyi City,nike air max 2009, a coal company for coal mining enterprises under the five charges, has seven times to a large Camp Branch of Taiyuan City Commercial Bank 9.87 million yuan loans . Tian Wang when he was head of the line , and the loan officer did not verify the temperature of flowers in the loans business ownership and value of collateral , nor mortgage registration , while not as collateral minerals , in violation of laws and regulations related to the case of loans , Will be 9.87 million yuan lending . As of November 20,nike free sale, 2008 , the loan principal amount of 9.07 million yuan enterprises owe the bank , interest of 900 million yuan , the bank repeated collection ,nike free 3.0, business owners refuse to return .

1998年8 months and 12 months, field verification of the macro without Lee and two other loan officers handle loan companies named Ma ownership and value of collateral , nor has mortgage registration case For woodworking machinery sales company in Taiyuan loans 1.2 million yuan . To November 20, 2008 , the loan company only returned 8 million principal amount , 5 million interest. Xiaodian District Court held that the macro and the temperature field flowers as Bank staff,nike air max skyline, in violation of state lending regulations , including Tian Hong involving 11.07 million yuan , involving 9.87 million yuan flower temperature , resulting in significant losses in particular , both constitute a violation issued Loans crime. Tian Wang and Wen flowers points were 6 years and 5 years imprisonment and a half minutes fined 120,000 yuan and 10 yuan.
( Editor : SN020)

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910,000 yuan bribes, embezzlement of 1.5 million, the former National People's Congress Standing Committee of Zhengzhou City, deputy director of science, education Jian Wei, the first instance by new city of Zhengzhou People's Court sentenced to 13 years and confiscation of property value of 810,000 yuan. Zhengzhou Intermediate Court of Final Appeal upheld the original verdict.
news correspondent Wangsong Bo Wang Hongwei Wang Junfeng

reflects environment Everyday, by spamming garbage fiscal

1957 Wei Kan born college graduates.
prosecution allegations, 2001-2004, Jian Wei Jinshui District People's Government when he was in Urban Construction Management Office during the City Council met Gao Long retired workers. Wei Jian found high in private, saying that a company hopes to make money and operate with Kan,air max 90, such as garbage collection works will make their operations.
that time, Jian Wei is in charge of the demolition work Jinshui, engineering to whom, Kan final say. Reflects environment Everyday, Gao Long said, as long as some of Jian Wei allow their trash to undertake the project, make a hundred million a year to mention.
Jian Wei move the heart, from 2002 to 2004, the Kan advantage of his office, has to undertake a high-Zheng Bian Road, Bear River children, commerce Road, Jin Shui overpass demolition waste, and several other places removal and transportation projects, and its introduction to undertake the demolition of the temple LI garbage removal project and other projects. Gao Long did not let go, Wei Jian has divided several times to commission a total of 800,000 yuan. After The investigation,cheap nike shoes, Jian Wei to take the money and let his wife bought a suite in Beijing.
addition to Gao Jun Long, Jian Wei also with another company of Prosecution allegations, Jian Wei also used his office,2010 air max, some of the garbage collection works to Zhang Jianfeng, Jian-Feng Zhang a total of three times 11 million to its commission.
final and bribery corruption, jailed for 13 years

Xinmi City People's Court of First Instance held that the defendant Wei Jian national staff who, using his office to illegally accepting property of others, to seek benefits for others; its national staff who,nike air max 2010, using his position to facilitate, the use of fraudulent means to illegal possession of public property, his acts were Bribery, corruption and crime.
Jian Wei justice for accepting bribes, the initiative has not yet mastered the judicial statement of the facts of the crime of corruption, embezzlement committed to its surrender punished. After the incident, Jian Wei initiative to withdraw proceeds of 95,000 yuan, the discretion of their sentences.
end, the court of taking bribes and sentenced him to twelve years and six months imprisonment and confiscation of property worth 815,000 yuan; guilty of embezzlement and sentenced to one year, decided to merge the implementation of ten years imprisonment and confiscation of property worth 815,000 yuan.
and Gao Long, Zhang Jianfeng to seek illegitimate interests, and national staff to property, their behavior constitutes the crime of bribery and sentenced to imprisonment for one year and six months Gao Long,air max 2009, sentenced to a term of imprisonment Zhang Jianfeng years, suspended for one year.
recently closed Zhengzhou Intermediate Court of Final Appeal upheld the original verdict.